As a result of the PRIHS 6 competition, Alberta Innovates invested in six projects with a total funding of $6.3 million. Projects are to run from June 2021 to November 2024.
| Researcher | Project Title | Institution | Award Amount |
| Vincent Agyapong | Reducing inpatient readmission rates for patients discharged from acute psychiatric care in Alberta using peer and text message support | University of Alberta | $979,868 |
| Mark Hamilton | Reducing Ventricular/Lumbar Drain and Ventricular Shunt Insertion Infections in the Neurosurgery, Trauma, and ICU Patient Population in Alberta | University of Calgary | $942,262 |
| Matthew Hicks | The Alberta Neonatal Abstinence Syndrome Mother-Baby Care ImprovEmeNT (NASCENT) Program: A stepped wedge cluster randomized trial of a hospital-level Neonatal Abstinence Syndrome intervention | University of Alberta | $1,264,750 |
| Oleksa Rewa | Improving the delivery of acute dialysis to critically ill patients in Alberta – DIALYZING WISELY | University of Alberta | $830,255 |
| Shannon Ruzycki/Anna Cameron | A Perioperative Glycemic Management Pathway for Reducing Length of Stay in Albertan Surgical Patients | University of Calgary | $1,287,838 |
| Mark Swain | Eliminating hepatitis C in Alberta is feasible and cost-effective | University of Calgary | $986,166 |